Formulation and Evaluation of Extended- Release Tablet of Zolpidem Tartrate by Wet Granulation Technique

Authors

  • Fatemeh Pourhashem Department of Pharmaceutics, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran
  • Mohammad Reza Avadi Department of Nanotechnology, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran
Abstract:

The goal of this study was to design and evaluate extended - release system of the hypnotic agent, Zolpidemtartrate usefulness for the treatment of insomnia. The half-life of this drug is about 1.9 - 3 hours that indicatingit a candidate for the extended release formulation. Our investigation relates to development of extendeddrug delivery system based on Hydroxy propyl methyl cellulose (HPMCK4M) as release retardant, polyvinylpyrrolidone (PVP k30) as binder and Magnesium Stearate using Factorial design. In vitro release study ofmatrix tablets was carried out in 0.01N HCl for 2 hours. All prepared matrix tablets were evaluated forphysicochemical evaluation and drug content. The formulation that had release profile according to UnitedState Pharmacopoeia selected for stability study according to ICH guidelines

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Journal title

volume 4  issue 1

pages  35- 41

publication date 2016-06-19

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